The endocannabinoid system, named after the plant that led to its discovery, is the universal, omnipresent system of internal regulation, cellular communication and homeostasis. It plays a very important role in establishing and maintaining human health. It is present in humans, animals and plants alike, except insects. It is believed that this system appeared about 500 million years ago and kept on evolving1.
The discovery of this system was a result of significant research since 1964.That year, famous Israeli scientist Professor Mechoulam, and his team isolated THC, Δ⁹-Tetrahydrocannabinol, the most abundant part of cannabis responsible for its psychoactive effects, feeling of euphoria and sedation2.
This discovery opened the doors to a better understanding of how our body and brain function. Further research led to the isolation of over 100s of other cannabinoids and the most famous cannabinoid, cannabidiol also known as CBD. In comparison to THC, CBD is the second most abundant, non-psychoactive part of the cannabis plant3.
In the 1990s, researchers cloned cannabinoid receptors that are present throughout the human body, these are CB1 and CB2 receptiors.
CB1 receptors, mostly found in the central nervous system2.
CB2 receptors mostly found in the immune system and its associated structures2.
Following the discoveries of exogenous, plant cannabinoids, scientists isolated endogenous cannabinoids also known as endocannabinoids: anandamide and 2-AG. These molecules are naturally produced in human bodies. Both endocannabinoids and THC are similar in molecular structure and interact with cannabinoid receptors, based on key and lock analogy1.
The endocannabinoid system consists of three major components1,2,4.
This system is involved in the regulation of many physiological processes including1:
In short, its role can be described as controlling eat, sleep, relax, forget, and protect functions5. These basic functions of the endocannabinoid system were summarized in 1998 by Professor Di Marzo.
Endocannabinoid system in action explained
The overall process is more complicated, this is just a simple explanation of the ECS in action to convey it’s core functions. In summary, the ECS works to maintain homeostasis.